Leptin Resistance and Obesity

obesity, leptin and leptin receptors

Increased serum leptin indicates leptin resistance in obesity.

Featured Article: Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5. This study was done at a very exciting time in the field of obesity research. Jeffrey Friedman’s group had published the landmark report in December 1994 that described the cloning of the Lep (...

Hormone Resistance in Diabetes and Obesity: Insulin, Leptin, and FGF21

This an edited transcript of the Lee E. Farr Lecture given by Dr. Jeffrey Flier on May 8, 2012, at the culmination of the annual Student Research Day at the Yale School of Medicine. In this presentation, Dr. Flier discusses his and his wife's research on insulin, leptin, and FGF21 in the context of his reflections upon his life's work and his advice for young investigators.

LEPTIN RESISTANCE: A PREDIPOSING FACTOR FOR DIET-INDUCED OBESITY Running title: Leptin resistance

Obesity is a resilient and complex chronic disease. One potential causative factor in the obesity syndrome is leptin resistance. Leptin behaves as a potent anorexic and energy-enhancing hormone in most young or lean animals, but its effects are diminished or lacking in the obese state associated with a normal genetic background. Emerging evidence suggests that leptin resistance predisposes the ...

Effect of obesity and serum leptin level on clopidogrel resistance.

OBJECTIVE Clopidogrel inhibits platelet aggregation by blockade of platelet adenosine diphosphate (ADP) P2Y12 receptor. Leptin is the obesity gene product, and its serum level increases with obesity. Platelets have leptin receptors on their surfaces. Hyperleptinemia may induce ADP-mediated platelet aggregation. It has been proposed that clopidogrel effect could be diminished with high serum lep...